Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.
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منابع مشابه
Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.
The relative roles of the sympathetic nervous system and renin-angiotensin system in the development of two-kidney renal hypertension were studied using four groups of rats: Group I = vehicle control; Group II = 6-OH-dopamine (2 weeks prior to renal clipping then weekly throughout the study); Group III = adrenal medullectomy plus vehicle; Group IV = 6-OH-dopamine plus adrenal medullectomy. Six ...
متن کاملSurgical reversal of two-kidney one clip hypertension during inhibition of the renin-angiotensin system.
Conscious rats with two-kidney one clip Goldblatt hypertension had the constricting clip removed during continuous infusion of either dextrose, saralasin, or captopril. Other dextrose-infused animals underwent removal of the ischemic kidney or a sham procedure. Direct arterial blood pressure (BP) was recorded throughout the 15-hour preoperative and subsequent 24-hour postoperative period. Rats ...
متن کاملVascular renin-angiotensin system in two-kidney, one clip hypertensive rats.
The possible role of the renin-angiotensin system in the maintenance of hypertension in two-kidney, one clip hypertensive rats was studied. Plasma renin activity rose rapidly and markedly in association with the elevation of blood pressure and then decreased gradually, although blood pressure remained high. Renin activity in the lung, aorta, and mesenteric artery also increased with the develop...
متن کاملIncreased angiotensin-converting enzyme activity of aorta in two-kidney, one-clip Goldblatt hypertension in rats.
There is increasing evidence that conversion of angiotensin I into angiotensin I1 can occur in the renal vasculature of humans [l l , and in the vascular beds of the hind limb of the dog 121. In previous experiments the specific angiotensionconverting enzyme in rat aorta [31 has been demonstrated. More recently, Mizuno et al. [41 have studied the subcellular localization of the enzyme activity ...
متن کاملEffects of angiotensin inhibition and renal denervation in two-kidney, one clip hypertensive rats.
Neural and angiotensin-mediated influences that alter hemodynamic and excretory behavior of the nonclipped kidney of two-kidney, one clip hypertensive rats were assessed by sequential acute surgical denervation of the nonclipped kidney and intravenous infusion of converting enzyme inhibitor (SQ 20881), 3 mg/kg X hr. Normal and two-kidney, one clip hypertensive rats (0.2-mm silver clip on the ri...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1980
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.2.6.723